Computer Science ETDs

Publication Date

5-1-2010

Abstract

A variety of tasks are typically performed after a phylogenetic reconstruction proper -- tasks which fall under the category phylogenetic post-analysis. In this dissertation, we present novel approaches and efficient algorithms for three post-analysis tasks: taking distances between (typically, all pairs in a set of) trees, bootstrapping, and building consensus trees. For instance, it is often the case that reconstruction finds multiple plausible trees. One basic way of addressing this situation is to take distances between pairs of trees, in order to gain an understanding of the extent to which the trees disagree. The most frequently employed manner for computing the distance between a tree pair is the Robinson-Foulds metric, a natural dissimilarity measure between a pair of phylogenetic trees. We present a novel family of algorithms for efficiently computing the Robinson-Foulds metric. Bootstrapping is a post-analysis technique for drawing support values on tree edges, and is often used for assessing the extent to which the underlying data (e.g., molecular sequences) supports a reconstructed tree. The basis of the approach is to reconstruct many trees, called replicates, based on random subsampling of the original data. However, to date, there has been little treatment in phylogeny regarding the question of how many bootstrap replicates to generate. We propose bootstopping criteria which are designed to provide on-the-fly (i.e., runtime) guidance for determining when enough bootstrap replicates have been reconstructed. Another common post-analysis task is to build a consensus tree, a summary tree that attempts to capture the information agreed upon by bootstrap replicates. Unfortunately, the most popular consensus methods are susceptible to confusion by rogue taxa, i.e., taxa that cannot be placed with assurance anywhere within the tree. We present novel theory and efficient algorithms to identify rogue taxa, as well as a novel technique for interpreting the results (in the context of bootstrapping).

Language

English

Keywords

computational biology, algorithms

Document Type

Dissertation

Degree Name

Computer Science

Level of Degree

Doctoral

Department Name

Department of Computer Science

First Committee Member (Chair)

Stamatakis, Alexandros

Second Committee Member

Moore, Cristopher

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