Chemistry and Chemical Biology ETDs

Publication Date

4-27-1979

Abstract

Many planar molecules or molecules with planar moieties have been shown to bind to DNA by intercalation, which can be defined as the insertion of a planar moiety between adjacent bases on the DNA strand, reading in the 3'-5' direction, accompanied by a partial unwinding and elongation of the helix in the immediate vicinity of the intercalation site. Intercalation raises the question of specificity of binding of the drug to DNA, since there are 16 possible intercalation sites in normal double-stranded DNA. The conformational changes (elongation and unwinding) associated with intercalation make circular dichroism (CD) an excellent technique for studying this type of binding.

Language

English

Document Type

Dissertation

Degree Name

Chemistry

Level of Degree

Doctoral

Department Name

Department of Chemistry and Chemical Biology

First Committee Member (Chair)

Ulrich Hollstein

Second Committee Member

William Fletcher Coleman

Third Committee Member

Fritz Schreyer Allen

Fourth Committee Member

Cary Jacks Morrow

Fifth Committee Member

Illegible

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