The Synthesis of 1-Methyl-3,4-Benzpyrene, 8-Methyl-3,4-Benzpyrene and 1,8-Dimethyl-3,4-Benzpyrene

Author

William Carter Doyle

Publication Date

12-16-1955

Abstract

The search for the carcinogenic factor present in crude oil tar fractions was begun around 1915. With the observation that the high-boiling, most carcinogenic fractions exhibited fluorescence spectra similar to those of many polycyclic aromatic hydrocarbons, several synthetic hydrocarbons were tested (1) on mice by skin painting techniques. Tumors were produced by 1,2,5,6-dibenzanthracene (I), 3'-methyl-1,2,5,6-dibenzanthracene (II) and 6-isopropyl-1,2-benzanthracene (III). One of the most widely used synthetic hydrocarbon carcinogens at the present is 1,2,5,6-dibenzanthracene.

Project Sponsors

National Cancer Institute of the United States Public Health Service

Language

English

Document Type

Dissertation

Degree Name

Chemistry

Level of Degree

Doctoral

Department Name

Department of Chemistry and Chemical Biology

First Committee Member (Chair)

Guido Herman Daub

Second Committee Member

John Francis Suttle

Third Committee Member

Milton Kahn

Fourth Committee Member

Unknown

Fifth Committee Member

Jesse LeRoy Riebsomer

Recommended Citation

Doyle, William Carter. "The Synthesis of 1-Methyl-3,4-Benzpyrene, 8-Methyl-3,4-Benzpyrene and 1,8-Dimethyl-3,4-Benzpyrene." (1955). https://digitalrepository.unm.edu/chem_etds/113