Chemical and Biological Engineering ETDs

Publication Date

Spring 5-12-2019

Abstract

With all its complexities and different biofunctionalities, a cell is the basic structural and functional unit of all living organisms with the exception of viruses. In this dissertation, I demonstrated gain of function strategies of modifying mammalian cells using silicification and modular nanoparticle (NP) exoskeletons. In addition, I used a modular design concept to build a multifunctional artificial RBC system which can mimic the unique characteristics (e.g. shape, flexibility, the ability to carry oxygen, and long circulation times) of the native RBCs. Together, these cell modification or artificial cell construction strategies are expected to generate new mammalian cell-like structures with potential applications in biosensor, bioreactors and cell based therapy developments, as well as providing new platforms for carrying out cell biology studies.

Document Type

Dissertation

Language

English

Degree Name

Chemical Engineering

Level of Degree

Doctoral

Department Name

Chemical and Biological Engineering

First Committee Member (Chair)

C. Jeffrey Brinker

Second Committee Member

Bryan Kaehr

Third Committee Member

Nick J. Carroll

Fourth Committee Member

Eva Chi

Fifth Committee Member

Atul N. Parikh

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