"Antimicrobial Activity and Photostability of Cationic Conjugated Polye" by Mohammed Ismael Khalil
 

Chemical and Biological Engineering ETDs

Publication Date

Fall 11-15-2024

Abstract

Antimicrobial resistance is a growing global health concern, driving the need for novel

therapeutic strategies. This study explores the antimicrobial efficacy of conjugated

polyelectrolytes (CPEs) and oligo-phenylene ethynylenes (OPEs) in bacterial and viral

inactivation. Quantitative analysis revealed that light-activated CPEs and OPEs

effectively reduced bacterial viability within minutes, with significant log reductions

observed under both light and dark conditions. Additionally, the antiviral potential of a

cationic conjugated oligomer was investigated, demonstrating rapid and near-complete

inactivation of SARS-CoV-2 under visible light, both in solution and on filter materials.

Further analysis of their photophysical properties revealed that, even after

photobleaching, the compounds retained strong antimicrobial activity, primarily through

singlet oxygen generation. Overall, this research underscores the promising role of

CPEs and OPEs as versatile antimicrobial agents in the fight against drug-resistant

bacteria and viral pathogens.

Document Type

Dissertation

Language

English

Degree Name

Chemical Engineering

Level of Degree

Doctoral

Department Name

Chemical and Biological Engineering

First Committee Member (Chair)

David G. Whitten

Second Committee Member

Eva Y. Chi

Third Committee Member

William P. Bricker

Fourth Committee Member

Jeremy Edwards

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