Biomedical Engineering ETDs
Publication Date
Fall 12-15-2024
Abstract
Respiratory disease is ranked one of the leading causes of death globally. If the mechanism of disease is understood the discovery and screening of potential pharmaceuticals and diagnostic tools will likely follow. Human in vitro lung models have provided the opportunity to closely mimic the respiratory system to test exposures. This work investigated the utilities of human in vitro lung cell models for radiological particulate toxicity and biomarker discovery, the screening of peptide countermeasures against host-virus interactions, and the differential gene expression between culture conditions for more effective experiments. The results demonstrate how effective in vitro models can be for toxicology, drug screening, and biomarker discovery and the importance of model parameter selection being based on experimental objectives. The results of this work are intended to improve the understanding of in vitro models and how they are best implemented.
Language
English
Keywords
Model-selection, radiation, toxicology, drug-screening, biomarkers
Document Type
Dissertation
Degree Name
Biomedical Engineering
Level of Degree
Doctoral
Department Name
Biomedical Engineering
First Committee Member (Chair)
Steven W. Graves
Second Committee Member
Jennifer F. Harris
Third Committee Member
Andrew P. Shreve
Fourth Committee Member
Harshini Mukundan
Fifth Committee Member
Matthew J. Campen
Recommended Citation
Moore, Shepard Christian. "Utility of Different Human Lung Cell Models for Toxicology, Drug Screening, and Biomarker Discovery." (2024). https://digitalrepository.unm.edu/bme_etds/48
Included in
Biological Engineering Commons, Medical Toxicology Commons, Other Medicine and Health Sciences Commons, Respiratory Tract Diseases Commons
Comments
Sixth Committee Member: Graham S. Timmins