Biomedical Sciences ETDs
Publication Date
Spring 5-16-2026
Abstract
Glioblastoma (GBM) is the most common malignant brain tumor in adults with a 5-year survival of approximately 7%. The extensive heterogeneity between GBM patients (intertumor) and within the same tumor (intratumor) plays a fundamental role in treatment resistance and tumor recurrence. This work highlights the importance of dissecting GBM inter- and intra- tumor heterogeneity for the identification of new therapeutic approaches. Chapter 2 presents a comprehensive review on GBM inter- and intra- tumor heterogeneity and highlights the importance of fluorescence-guided multiple sampling for the dissection of GBM heterogeneity. Chapter 3 presents a study on the characterization of the tumor microenvironment in GBM patients and the identification of potential targets for treatment. Finally, chapter 4 focuses on a study to dissect the functional impairment of wt p53 in GBM by highlighting differences between wt and mutant TP53 GBM patients that could be relevant for the identification of potential therapeutic targets.
Keywords
Glioblastoma, Heterogeneity, Brain tumors, TP53, Tumor supressor
Document Type
Dissertation
Language
English
Degree Name
Biomedical Sciences
Level of Degree
Doctoral
Department Name
Biomedical Sciences Graduate Program
First Committee Member (Chair)
Huining Kang
Second Committee Member
Sara Piccirillo
Third Committee Member
Tou Yia Vue
Fourth Committee Member
Xing Fan
Recommended Citation
Garcia Montano, Leopoldo Alfredo. "DISSECTING THE FUNCTIONAL IMPAIRMENT OF WILD-TYPE P53 IN HUMAN GLIOBLASTOMA." (2026). https://digitalrepository.unm.edu/biom_etds/316