Biomedical Sciences ETDs

Publication Date

Fall 12-12-2020

Abstract

This dissertation aims to determine if adult hippocampal neurogenesis is a potential therapeutic target in Fetal Alcohol Spectrum Disorders (FASDs). Adult hippocampal neurogenesis plays important and unique roles in certain aspects of learning, memory, and mood (Anacker & Hen, 2017). Individuals with FASDs often demonstrate dysregulation in these arenas (Lewis et al., 2015; Temple, Cook, Unsworth, Rajani, & Mela, 2019). Previous work in our lab using a mouse model of prenatal alcohol exposure demonstrated impairment in enrichment-mediated adult hippocampal neurogenesis (Irene Y. Choi, Andrea M. Allan, & Lee Anna Cunningham, 2005; K. Kajimoto, A. Allan, & L. A. Cunningham, 2013). This provoked further investigation as moderate exposure, the most common pattern of consumption among pregnant women (Mary K. Ethen, Tunu A. Ramadhani, Angela E. Scheuerle, Mark A. Canfield, Diego F. Wyszynski, Charlotte M. Druschel, Paul A. Romitti, et al., 2009), could have implications for interventions targeting improvement in hippocampal-dependent behaviors.

Keywords

Neurogenesis, FASD, PAE, Hippocampus, Enrichment

Document Type

Dissertation

Language

English

Degree Name

Biomedical Sciences

Level of Degree

Doctoral

Department Name

Biomedical Sciences Graduate Program

First Committee Member (Chair)

Lee Anna Cunningham

Second Committee Member

Fernando Valenzuela

Third Committee Member

Jonathan Brigman

Fourth Committee Member

Jennifer Gillette

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