Biomedical Sciences ETDs
Publication Date
Fall 12-18-2021
Abstract
HPV is the most common sexually transmitted infection. It is estimated that 80% of sexually active adults will contract an HPV infection. Thus, there is a significant need for low-cost and easily distributable HPV antivirals that can be used alongside vaccines to combat infection. Herein I have identified protamine sulfate (PS) as a potent microbicide against HPV infection. PS was agnostic to genotype and efficacious pre and post HPV exposure. PS application topically reduced HPV internalization by altering epidermal growth factor receptor (EGFR) signaling and suppressed EGFR-stimulated HPV entry. Our preliminary data also suggest that heparin binding epidermal growth factor (HB-EGF) instead of EGF drives signaling important for HPV infection. Moreover, we describe a novel mediator of HPV infection, vascular endothelial growth factor receptor (VEGFR). Overall, our findings suggest PS is a potent microbicide, and that EGFR and VEGFR signaling is important for mediating HPV infection.
Keywords
HPV, EGFR, VEGFR, HSPG, Infection, Protamine, HB-EGF, Prophylactics
Document Type
Dissertation
Language
English
Degree Name
Biomedical Sciences
Level of Degree
Doctoral
Department Name
Biomedical Sciences Graduate Program
First Committee Member (Chair)
Michelle A. Ozbun, Ph.D.
Second Committee Member
Angela Wandinger-Ness, Ph.D.
Third Committee Member
Diane S. Lidke, Ph.D.
Fourth Committee Member
Adriana E. Kajon, Ph.D.
Recommended Citation
Young, Jesse McKay. "ARGININE-RICH POLYPEPTIDES ARE POTENT INHIBITORS OF HUMAN PAPILLOMAVIRUS INFECTION AND POWERFUL TOOLS TO INVESTIGATE VIRAL ATTACHMENT AND ENTRY." (2021). https://digitalrepository.unm.edu/biom_etds/303
Included in
Immunology and Infectious Disease Commons, Medicine and Health Sciences Commons, Molecular Biology Commons
Comments
Fixed minor formatting errors after initially review by Mayra Estrada.