Biomedical Sciences ETDs
Publication Date
Fall 11-14-2019
Abstract
Hardrock mining in the United States (US) has left a legacy of mixed metal mine waste sites. Wastes may contain multiple metals of health concern, including arsenic, cadmium, lead, mercury, and uranium, among others. Mining waste sites are disproportionately located on or contiguous to the watersheds of tribal lands. Due to proximity, and because of reliance on natural resources to maintain traditional diets and customs, Native American communities’ contact with multiple metals is often increased. Two impacted communities are the Cheyenne River Sioux Tribe (CRST) and Navajo Nation. Both tribes have expressed concerns that metals in mine waste adversely affect their communities’ health and report an elevated prevalence of autoimmune diseases. To examine the effects of mixed metals, we measured metals and autoimmune-associated markers. We found that metals and metal mixtures are associated with alterations in certain autoimmune markers such as autoantibodies and cytokines.
Keywords
metals immune autoimmune cytokines autoantibodies uranium arsenic indigenous
Document Type
Dissertation
Language
English
Degree Name
Biomedical Sciences
Level of Degree
Doctoral
Department Name
Biomedical Sciences Graduate Program
First Committee Member (Chair)
Johnnye Lewis
Second Committee Member
Debra MacKenzie
Third Committee Member
Laurie Hudson
Fourth Committee Member
Robert Rubin
Recommended Citation
Ong, Jennifer. "CHRONIC ENVIRONMENTAL EXPOSURE TO METAL MIXTURES IN TRIBAL POPULATIONS AND POTENTIAL IMMUNE SYSTEM EFFECTS." (2019). https://digitalrepository.unm.edu/biom_etds/207