Biology ETDs

Publication Date

Summer 7-2-2025

Abstract

The immune system of most jawed vertebrates consists of three major cell types: αβ T cells, γδ T cells, and B cells. Every species evaluated contains the loci that encode the highly conserved αβ T cells, however, γδ T cells are less conserved and have been lost in squamate reptiles. The loci that encode the B cell receptor have also varied across evolution. Seven immunoglobulin (Ig) heavy chain isotypes have been identified in amniotes: IgM, IgD, IgY, IgG, IgE, IgO, and IgA. Some are found in most species (IgM and IgD) and others only in specific lineages (IgY or IgG). The number of Ig subclasses can also vary. For example, there is only one IgG found in all marsupials. The work presented in this dissertation are aimed at investigating the evolutionary history of gain and loss in the vertebrate immune systems and its functional impact.

Language

English

Document Type

Dissertation

Degree Name

Biology

Level of Degree

Doctoral

Department Name

UNM Biology Department

First Committee Member (Chair)

Robert D. Miller

Second Committee Member

Ellen O. Martinson

Third Committee Member

Judy L. Cannon

Fourth Committee Member

Michael F. Criscitiello

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