Transcriptional silencing of CDK18 and its role in lung carcinogenesis of BRG1-mutant lung cancers

Author

Loryn M. Phillips, University of New Mexico - Main CampusFollow

Publication Date

Spring 4-15-2023

Abstract

BRG1 is mutated in 10% of lung cancers, making this mutation clinically relevant. The downstream effects of BRG1 included significantly affecting the cell cycle control and chromosomal replication pathway. CDK18, a cyclin-dependent kinase, was determined to be the gene with significantly decreased expression (p

Project Sponsors

Lovelace Biomedical Research Institute (RO1 CA196590)

Language

English

Keywords

Cancer, Biology, Epigenetic, Lung, Lung Cancer, BRG1, CDK18, Cell Cycle, Transcription

Document Type

Thesis

Degree Name

Biology

Level of Degree

Masters

Department Name

UNM Biology Department

First Committee Member (Chair)

Christopher A Johnston

Second Committee Member

Helen Wearing

Third Committee Member

Steven A Belinsky

Recommended Citation

Phillips, Loryn M.. "Transcriptional silencing of CDK18 and its role in lung carcinogenesis of BRG1-mutant lung cancers." (2023). https://digitalrepository.unm.edu/biol_etds/380