The Effects of Desoxycorticosterone Trimethylacetate, Desoxycorticosterone Acetate, Cortisone Acetate, and Adrenalectomy on the Liver Succinoxidase and Glutamic Dehydrogenase Activity of Rats Fed 3'-Methyl-4-Dimethylaminoazobenzene (3'-Me-DAB)

Author

John P. DaVanzo

Publication Date

6-12-1957

Abstract

Experimental production of liver cancer by means of azo dyes is a standardized and convenient method for study of the cancer problem. The rat is the animal of choice for this type of experimentation because this animal is readily susceptible to liver carcinogenesis upon being fed azo dyes. Mice are only partially susceptible and rabbits and guinea pigs will not develop cancer of the liver by ingestion of the azo dyes (E. C. Miller and J. A. Miller, 1947, p.473). The liver, likewise, is an appropriate organ for study. Enzymologists and cytologists today regard the liver cell as the best known somatic cell. The structure and function of the liver are well understood and amendable to experimentation. Its response to dietary changes, to endocrine changes, and to toxic agents has been thoroughly investigated. Indeed, endeavor from these and various other fields are beginning to become co-ordinated and to fit into a logical pattern that helps explain the enigma of the carcinogenic process.

Language

English

Document Type

Dissertation

Degree Name

Biology

Level of Degree

Doctoral

Department Name

UNM Biology Department

First Committee Member (Chair)

Wilburn John Eversole

Second Committee Member

Howard J. Dittmer

Third Committee Member

Clarence Clayton Hoff

Recommended Citation

DaVanzo, John P.. "The Effects of Desoxycorticosterone Trimethylacetate, Desoxycorticosterone Acetate, Cortisone Acetate, and Adrenalectomy on the Liver Succinoxidase and Glutamic Dehydrogenase Activity of Rats Fed 3'-Methyl-4-Dimethylaminoazobenzene (3'-Me-DAB)." (1957). https://digitalrepository.unm.edu/biol_etds/283