Biology ETDs

Publication Date

1-17-1958

Abstract

Early changes in the serum concentrations of glutamic-oxalacetic transaminase, glutamic-pyruvic transaminase, lactic dehydrogenase, and malic dehydrogenase were determined in young adult rats following exposures to sublethal, midlethal, and supralethal doses of X-irradiation, treatment with hepatotoxic agents or opiates, and sequential administration of both X-irradiation and the hepatotoxins. Changes in serum enzyme content were also determined in a series of 38 rhesus monkeys within 30 minutes after exposure to sublethal doses of fission neutrons.

Relatively small increases in serum enzyme concentration, detectable within 1 to 6 hours after whole body X-irradiation, were greatly exaggerated by prior treatment of the test animals with chloroform or carbon tetrachloride. Codeine or demerol caused significant increases in the enzymes studied but generally antagonized the effects of X-rays on serum enzyme accumulation. Fission neutrons caused variable increases in the serum enzyme content as early as 30 minutes after exposure.

Document Type

Thesis

Degree Name

Biology

Level of Degree

Masters

Department Name

UNM Biology Department

First Committee Member (Chair)

W.J. Eversole

Second Committee Member

C. Clayton Hoff

Third Committee Member

William J. Koster

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