The ability to ambulate with a prosthesis after lower extremity limb loss is an important determinant of functional independence and quality of life. Some individuals may be capable of achieving higher levels of mobility (eg, running) that can further improve function, physical health, and mental health. Thus, a fundamental understanding of the variables that help predict ambulation ability after lower limb loss is important. Particular attention should be given to modifiable predictors, as interventions directed at these conditions can help facilitate optimal mobility and function. This article reviews various factors that influence the ability

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