Individuals with alcohol use disorder (AUD) are heterogeneous in terms of etiology, maintenance, symptoms, and recovery, yet current diagnostic categories fail to adequately capture this heterogeneity. Corresponding to the neurobiological addiction cycle, the Alcohol and Addictions Research Domain Criteria proposes a framework of three core domains disrupted in AUD: negative emotionality, incentive salience, and executive function. The Addictions Neuroclinical Assessment (ANA) is a hypothesized multimodal assessment battery of these three domains, which may better characterize AUD heterogeneity. The current study validated the ANA in a sample of drinkers (N=245) who were diverse with respect to ethnicity and alcohol treatment-seeking status. This ANA model demonstrated measurement invariance over time, across sex, and across Hispanic and non-Hispanic white ethnicity. Drinking, incentive salience, and negative emotionality decreased over time, but only change in negative emotionality was associated with change in drinking. Clinical implications, measurement considerations, and future directions for precision medicine are discussed.
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alcohol, addictions neuroclinical assessment, research domain criteria, precision medicine
Stein, Elena R.. "Validation of the Addictions Neuroclinical Assessment Among Diverse Individuals with Alcohol Use Disorder." (2023). https://digitalrepository.unm.edu/psy_etds/406