Viral respiratory infections are a leading cause of illness and hospitalization in young children worldwide. Case fatality rates in pediatric patients with adenoviral lower respiratory tract infection requiring intensive care unit (ICU) admission have been reported between 7 and 22%. We investigated the demographics and clinical characteristics in pediatric mortalities associated with adenoviral respiratory infection at 12 academic children's hospitals in the United States. There were 107 mortality cases included in our study, 73% of which had a chronic medical condition. The most common chronic medical condition was immunocompromised state in 37 cases (35%). The incidences of pediatric acute respiratory distress syndrome (78%) and multiple organ dysfunction syndrome (94%) were profound. Immunocompetent cases were more likely to receive mechanical ventilation within the first hour of ICU admission (60 vs. 14%,
J Pediatr Intensive Care
Spaeder MC, Stewart C, Sharron MP, Noether JR, Martinez-Schlurman N, Kavanagh RP, Signoff JK, McCrory MC, Eidman DB, Subbaswamy AV, Shea PL, Harwayne-Gidansky I, Ninmer EK, Sheram ML, Watson CM. Adenoviral Respiratory Infection-Associated Mortality in Children: A Retrospective Case Series. J Pediatr Intensive Care. 2020 Oct 26;11(1):13-18. doi: 10.1055/s-0040-1718868. PMID: 35178273; PMCID: PMC8843406.