Title

Dynamic re-immunization of off-treatment childhood cancer survivors: An implementation feasibility study.

Document Type

Article

Publication Date

1-1-2018

Abstract

There are no universally approved re-vaccination guidelines for non-transplant pediatric cancer survivors. We hypothesized that by utilizing a response-based re-vaccination schedule, we could tailor vaccine schedules in off-treatment cancer survivors. Pre-vaccination antibody levels were obtained in 7 patients at an average of 20 days after the end of treatment date. In those without protective antibody levels, we administered vaccines 3 months after completion of treatment. Revaccinating patients 3 months after the end of treatment date resulted in protective antibody levels for most vaccines. We showed, on a preliminary basis, that vaccinating non-transplanted pediatric cancer survivors can be dynamically implemented in children with recovering immune function.

Publication Title

PLoS One

ISSN

1932-6203

Volume

13

Issue

2

First Page

0191804

Last Page

0191804

DOI

10.1371/journal.pone.0191804

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