Background: Near-infrared spectroscopy (NIRS) is a non-invasive technique for monitoring regional oxygenation of underlying tissues and has been well validated in neonates. Cerebral oxygenation may be a better predictor for risk of brain hypoperfusion and subsequent adverse neurodevelopmental outcomes than standard hemodynamic monitoring parameters. Low or fluctuating cerebral oxygenation has been shown to be associated with increased risk of intraventricular hemorrhage (IVH), adverse neurodevelopmental outcomes, and death in preterm infants. Reference ranges for cerebral oxygenation in the first several days of life using NIRS have been published for preterm (<37 >weeks’ gestation) infants born at sea level, but no published data is currently available for those born at high altitude.
Methods: Prospective observational study of cerebral regional oxygen saturation and fractional tissue oxygen extraction for the first 96 hours of life in preterm infants born <32 >weeks’ gestational age in a high-altitude location (5174ft / 1577m). Demographic information, maternal prenatal history, and delivery information is recorded at time of enrollment. Cardiopulmonary monitoring parameters obtained throughout the NIRS monitoring period is recorded and information on common morbidities of prematurity are recorded at time of discharge or death. Anticipated
Results: Patient enrollment continues at this time. Reference values for cerebral oxygen saturation and fractional tissue oxygen extraction over the first 96 hours of life (mean and interquartile ranges) for preterm infants born <32 >weeks’ gestational age at high altitude will be obtained. Any correlations between cerebral oxygenation and common morbidities of prematurity will be assessed. Sub-group analysis by gender and gestational age will be conducted if reasonable based on number of participants. Next Steps: Data collection and statistical analysis are currently ongoing.
Enright, Leah; Dawn Novak; and Jessie R. Maxwell. "Utilization of Near-Infrared Spectroscopy Technology to Determine Normative Cerebral Regional Oxygen Saturation in a Preterm Population Born at Altitude." (2022). https://digitalrepository.unm.edu/hsc_2022_pediatric_research/11