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Spreading depolarizations (SDs) have been strongly linked to advancing secondary injury in ischemic stroke but may also provide beneficial effects to brain tissue that is not metabolically depleted. In the current study, we sought to identify whether SDs initiated remotely can alter secondary injury expansion. Infarct size was significantly reduced in mice with transient MCAo when SDs were induced in brain regions located outside of the vulnerable stroke penumbra suggesting a neuroprotective effect of SD.

Funding: NS129351, NS106901, GM109089



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