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Fetal Alcohol Spectrum Disorders (FASD) affect the development of children prenatally exposed to alcohol. Severe forms of FASD involve altered structure and function of brain microvasculature. These alterations are partially mediated by an increase in the microRNA miR-150-5p in brain microvascular endothelial cells (BMVECs). We investigate molecular mechanisms that may cause increased miR-150-5p following alcohol exposure. These mechanisms may include altered DNA methylation and transcription factor binding at the miR-150 promoter.



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