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Prenatal alcohol exposure (PAE) impairs the migration of interneurons during brain development. As interneurons are involved in dentate gyrus synaptic plasticity and learning, we measured three different subtypes of interneurons in dentate gyrus and found a significant decrease in the density of parvalbumin-positive (PV+) neurons in both sexes of PAE rats. These results suggest that PV+ interneurons are particularly sensitive to moderate PAE and could contribute to differential physiological and behavioral responses in PAE rats.


Supported by P50 AA022534 and P20 GM109089.



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