KSRP Reduces the Migration and Invasion of Glioblastoma Cells and Restricts Angiogenesis of Human Brain Microvascular Endothelial Cells
Glioblastoma multiforme (GBM) is a highly aggressive and invasive brain tumor that has been continuously challenging to treat. Combined treatment strategies, including surgical resection, radiotherapy, and chemotherapy, have improved patient outcomes, however, median survival time is less than 15 months. Thus, there is a critical need for new therapeutic targets and approaches. KSRP is a multi-functional RNA-binding protein that acts post-transcriptionally to regulate mRNA stability, splicing, and transport, as well as the biogenesis and function of microRNAs and other non-coding RNAs. Several studies have shown that KSRP expression is significantly associated with prolonged survival of glioblastoma patients. We recently identified novel KSRP-dependent RNA targets, which are altered in glioblastoma cells. We are currently examining how KSRP interacts with and regulates its targets in glioblastoma cells. In addition, we are studying the effect of modulating KSRP and its targets on cellular processes such as tumor cell migration, invasion, and angiogenesis. This project will further our understanding of the molecular mechanisms by which KSRP and its targets impact tumor development and progression. In addition, this work may lead to strategies for targeted therapies against novel molecules and pathways.
Huynh, Pearl; Robert Oliver; Gabriela Perales; and Amy S. Gardiner. "KSRP Reduces the Migration and Invasion of Glioblastoma Cells and Restricts Angiogenesis of Human Brain Microvascular Endothelial Cells." (2023). https://digitalrepository.unm.edu/hsc-bbhrd/123
Poster presented at the Brain & Behavioral Health Research Day 2023