Comparison of Stereoelectroencephalography Versus Subdural Electrodes for Invasive Epilepsy Monitoring in Pediatric Patients: A Meta-aAalysis
Introduction: Stereoelectroencephalography (SEEG) and subdural explorations (SDE, including grids, strips, and depth electrodes) represent the two main techniques utilized in pre-operative evaluation of medically refractory epilepsy. During the past two decades, some studies have explored the comparative safety and effectiveness of these two modalities in pediatric patients.
Methods: We conducted a systematic review with meta-analysis following PRISMA guidelines. We performed literature search using MeSH terms published until June 30, 2022 in four electronic databases. The R statistical software version 3.5.3 and MedCalc Statistical Software version 19.2.3 were used to perform the meta-analysis.
Results: We included 16 studies with 780 pediatric patients who underwent SDE and 22 papers with 662 pediatric patients who underwent SEEG monitoring. Post-procedure complications were seen more frequently in SDE as compared to SEEG group. CSF leak was observed in 7.95% of patients (pooled prevalence; 95% CI: 3.3-14.38) in the SDE group as compared to a CSF leak prevalence of 0.62% (95% CI, 0.166-0.1613) in the SEEG group (Relative risk, RR, 56.82, p = 0.0001). Intracranial hemorrhages (ICHs) and infections were also observed more frequently in SDE group (RR, 2.212, p = 0.004; RR, 11.95, p < 0.0001). In the SDE group, ICH had a pooled prevalence of 4.88% (95% CI, 1.91-9.137) and infection had a pooled prevalence of 8.34% (95% CI 6.348-10.717). SEEG had an ICH prevalence of 3.54% (95% CI 2.184-5.402) and infection had a prevalence of 1.00% (95% CI 0.368-2.177). Among patients who underwent subsequent epilepsy surgery subsequently, the percentage of patients achieving seizure freedom (Engel class I) was similar between SDE and SEEG groups (SDE: 62.09%, 95% CI 51.03-72.55 versus SEEG: 64.91%, 95% CI 56.38-72.98, p = 0.965).
Conclusion: In a pooled analysis of pediatric patients, SEEG was associated with less adverse effects overall yet similar rates of seizure freedom compared to SDE.
Kazim, Syed Faraz; Michael Kogan; James A. Botros; Ariana Barkley; and Heather Stevens Spader. "Comparison of Stereoelectroencephalography Versus Subdural Electrodes for Invasive Epilepsy Monitoring in Pediatric Patients: A Meta-aAalysis." (2023). https://digitalrepository.unm.edu/hsc-bbhrd/104
Poster presented at the Brain & Behavioral Health Research Day 2023