Health, Exercise, and Sports Sciences ETDs

Publication Date

Spring 7-9-2022


PURPOSE: 1) Compare the effects of whole-body heat stress (HS) and resistance exercise (RE) on thermoregulatory responses and skeletal muscle heat shock and hypertrophy related signaling. 2) Examine the effects of acute heat stress (HEAT) on myotube growth and fusion compared to controls (CON), hypertrophy (HYPER), and atrophy (RAPA) treatments in-vitro. METHODS: 1) Eight healthy, physically active and resistance trained individuals (18-45 years) completed RE and HS. 2) 48 hours following treatments, C2C12 myotubes were assessed for myotube area and nuclear fusion index. RESULTS: 1) RE and HS similarly increased muscle but not core temperatures. HS but not RE increased HSPA1A/B protein expression, HSPC1-3 was unchanged. HS increased Akt-mTOR phosphorylation greater than RE. 2) HEAT increased myotube area greater than RAPA and CON, but to a lesser than HYPER. HEAT increased fusion index greater than RAPA and CON but was not different than HYPER.


Heat Stress, Skeletal Muscle, Heat Shock Proteins, Hypertrophy

Document Type




Degree Name

Physical Education, Sports and Exercise Science

Level of Degree


Department Name

Health, Exercise, and Sports Sciences

First Committee Member (Chair)

Christine Mermier

Second Committee Member

Fabiano Amorim

Third Committee Member

Michael Deyhle

Fourth Committee Member

Paul Hafen

Fifth Committee Member

Roberto Nava


Sixth Committee Member: Kurt Escobar