Health, Exercise, and Sports Sciences ETDs

Publication Date

Fall 12-17-2022


The effectiveness of perinatal exercise (i.e., exercise by mothers immediately prior to, throughout, and after pregnancy) to attenuate high-altitude pulmonary hypertension and associated health consequences in the offspring exposed to chronic hypoxia in early life was investigated. Four groups were used to compare the effects of perinatal exercise to offspring exposed to low altitude (i.e., normoxic) conditions or simulated 4500 meters of high altitude (i.e., hypoxic) as well as their respective, sedentary controls. Offspring in the hypoxic groups had lower body weights and tail lengths as well as higher hematocrits, right ventricular systolic pressures, and right heart weights. The hypoxic group whose mothers were physically active also had greater small pulmonary artery wall thickness, lower exercise capacity, and meaningfully, but not statistically, lower right ventricular systolic pressure compared to their sedentary counterpart. In conclusion, perinatal exercise produces small yet meaningful benefits in the offspring to combat high-altitude pulmonary hypertension development.


high-altitude, right ventricular systolic pressure, Rotarod, inflammation, voluntary wheel running

Document Type




Degree Name

Physical Education, Sports and Exercise Science

Level of Degree


Department Name

Health, Exercise, and Sports Sciences

First Committee Member (Chair)

Michael R. Deyhle

Second Committee Member

Ann L. Gibson

Third Committee Member

Laura V. Gonzalez Bosc

Fourth Committee Member

Christine Mermier

Fifth Committee Member

Sean M. Wilson

Available for download on Tuesday, December 17, 2024