Oligomeric Phenylene Ethynylenes (OPEs) are a class of synthetically prepared compounds with the basic structure of phenylene rings connected by triple-bonded carbon atoms, also known as an ethyne link. This structure can be modified by incorporating functional groups onto one or more of the phenylene rings. The addition of functional groups, such as sulfoxide or imidazole, may alter the photophysical properties in detectable ways. The photophysical techniques used in this report include fluorescence, spectroscopy in the ultraviolet and visible light range (UVVIS), and photon-based excitation using a photo chamber.
One attractive function of OPEs is their antimicrobial property. Previously published tests have shown that OPEs with different functional groups inactivate bacteria such as E. coli and damage viral components such as the spike proteins of SARS CoV-2 virus (COVID-19) (1). The method of inactivation is still being explored, but activation following exposure to broad-spectrum light seems to be an important component.
Dr. Eva Chi, Dr. David Whitten
Oligomeric Phenylene Ethynylene, UVVIS, Fluorescence, Singlet Oxygen, DLS, Vesicles, Phospholipids, Extrusion, SDS, Blue Shift
Level of Degree
Department of Chemistry and Chemical Biology
First Committee Member (Chair)
Dr. Stephen Cabaniss
Second Committee Member
Dr. Eva Chi
Third Committee Member
Dr. David Whitten
Fritz, Hugh F. Jr.. "PHOTOPHYSICAL PROPERTIES OF SYNTHETIC OLIGOMERIC PHENYLENE ETHYNYLENE." (2023). https://digitalrepository.unm.edu/chem_etds/196