The goal of this investigation is to study mechanisms the immune cell receptor, Dectin-1, uses to identify the fungal cell species, Candida albicans. Dectin-1 identifies extracellular matrix polysaccharides that Candida albicans express known as β-glucan. To study the interaction of β-glucan – Dectin-1 at the nanoscopic scale, the investigators of this project have endeavored to model the Candida albicans cell wall with engineered Self-Assembled Monolayers presenting β-glucan as a ligand for immobilized Dectin-1 receptors. By engineering a simplified ex-vivo model of the Candida albicans cell wall, the investigators of this study aim to gain precise control of the composition and structure of the delicate embedded nanostructured supra-molecular assemblies that define the cell wall of Candida albicans. The investigator has proposed developing the synthetic model of the cell wall using Self-Assembled Monolayers and Biotin-Streptavidin chemistry to host β-glucan polysaccharides as ligands.
Candida albicans, Beta-Glucan, Self-Assembled Monolayers, Streptavidin, Biotin
Level of Degree
First Committee Member (Chair)
Second Committee Member
Third Committee Member
Ghosh, Ushnik. "Developing a synthetic model of the Candida albicans cell wall using Self-Assembled Monolayers to host Beta-glucan as ligands." (2019). https://digitalrepository.unm.edu/bme_etds/23