Omega-3 polyunsaturated fatty acids (n-3 PUFAs) may lower cardiovascular disease risk by reducing blood pressure (BP). We hypothesized that fat-1 transgenic mice, which convert n-6 PUFAs to n-3 PUFAs, would have improved vascular function in BP regulation and following secondhand smoke (SHS) exposure, compared to wild type (WT) mice.
BP was recorded in mice fed an n-6 PUFA, or standard chow diet. On the n-6 PUFA diet fat-1 mice had a lower mean arterial pressure and a greater decrease in diastolic BP when treated with an ACE inhibitor, compared to WT mice. No differences were observed on the chow diet. Next, fat-1 mice on the n-6 PUFA or chow diet were exposed to SHS. SHS enhanced vasoconstriction on the n-6 PUFA diet, but not on chow, but did not affect vasorelaxation.
These data suggest n-3 PUFAs have a protective role in basal BP regulation and SHS-induced vascular dysfunction.
Omega-3 Polyunsaturated Fatty Acid, n-3 PUFA, Secondhand Smoke, Vascular Dysfunction, Blood Pressure, Fat-1
Level of Degree
Biomedical Sciences Graduate Program
First Committee Member (Chair)
Mary K. Walker
Second Committee Member
Matthew J. Campen
Third Committee Member
Dawn A. Delfin
Wheeler, Emily Anna. "The Role of Omega-3 Polyunsaturated Fatty Acids in Blood Pressure Regulation and Secondhand Smoke-Induced Vascular Dysfunction." (2019). https://digitalrepository.unm.edu/biom_etds/204