Chemistry and Chemical Biology ETDs
Publication Date
1954
Abstract
In 1953 Cook, Hewett, and Rieger found a highly carcinogenic hydrocarbon in coal tar. By a variety of solvent extraction methods, fractional distillation, and crystallization several pure hydrocarbons were isolated from the crude pitch. Two new pentacyclic aromatic hydrocarbons were isolated and since only small quantities of them were available it was decided to ascertain their structures by synthesis instead of degradetive experiments. The hydrocarbon samples were obtained with great difficulty from two tons of crude pitch. The problem was simplified since ten of the possible fifteen pentacyclic hydrocarbons were known. From certain similarities of these hydrocarbons to perylene its isomerides, namely the 1,2- and 3,4-benzpyrenes, were prepared and proved to be identical with the hydrocarbons isolated. Carcinogenic testing revealed that only the 3,4-benzpyrene was active.
Project Sponsors
National Cancer Institute of the United States Public Health Service
Language
English
Document Type
Thesis
Degree Name
Chemistry and Chemical Biology
Level of Degree
Masters
Department Name
Department of Chemistry and Chemical Biology
First Committee Member (Chair)
Guido Herman Daub
Second Committee Member
Milton Kahn
Third Committee Member
Raymond Castle
Fourth Committee Member
Paul William Healy
Recommended Citation
Adelfang, Jules. "The Synthesis of 10-methyl-3, 4-benzpyrene and 8,10-dimethyl-3, 4-benzpyrene." (1954). https://digitalrepository.unm.edu/chem_etds/53
