Chemistry and Chemical Biology ETDs

Publication Date

5-17-1961

Abstract

The antitumor activity found in such ring systems as the purine, pyrazolo [3,4-d] pyrimidine, and the 8-azapurine prompted the preparation of the imidazo [4,5-d] pyridazine ring system. Castle and Seese were one of the first to study this ring system. 4-Aminoimidazo[4,5-d]pyridazine possessed some anitumor activity. This antitumor activity suggested the preparation of the 4,7-disubstituted-aminoimidazo{4,5-d]pyridazines reported here. The antileukemic activity reported for 6-purinethiol led to the synthesis of several 4- and/or 7-mono-and disubstitutedthioimidazo[4,5-d]pyridazines.

Project Sponsors

Los Alamos Scientific Laboratory, the National Institute of Health

Language

English

Document Type

Dissertation

Degree Name

Chemistry

Level of Degree

Doctoral

Department Name

Department of Chemistry and Chemical Biology

First Committee Member (Chair)

Raymond N. Castle

Second Committee Member

Jesse LeRoy Riebsomer

Third Committee Member

Milton Kahn

Fourth Committee Member

Ernest Lynne Martin

Fifth Committee Member

Eugene Weston Rypka

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