Biomedical Sciences ETDs

Publication Date

9-20-1974

Abstract

Cells which are transformed by oncogenic viruses become malignant in their behavior. One aspect of t h is behavior is that the growth of such cells is no longer restrained by contact with other cells of their kind . The loss in contact inhibition is believed to result from structural and functional altercations in the plasma membranes of these cells. Of the may components of the membranes of virus-transformed cells which have been examined, lipids have received the least consideration. In the expectation that altered membrane function is a concomitant of altered lipid composition in these membranes, a study was carried out in which the major phospholipid, phosphatidyl choline, was extracted from the microsomal fraction of a normal cell line and also from that of a virus-transformed cell line of the same type. The structures of both phosphatidyl cholines were studied in detail and the two compared

Document Type

Dissertation

Language

English

Degree Name

Biomedical Sciences

Level of Degree

Doctoral

Department Name

Biomedical Sciences Graduate Program

First Committee Member (Chair)

Francis Newton Lebaron

Second Committee Member

Joseph Victor Scaletti

Third Committee Member

Sidney Solomon

Fourth Committee Member

Leonard M. Napolitano

Fifth Committee Member

Illegible

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