Antagonizing Serotonin 2A (5-HT2A) Receptors Does Not Attenuate Methamphetamine-Induced Expression of Conditioned Place Preference in Female and Male Rats
Despite the need, there are currently no FDA-approved pharmacological treatments for methamphetamine use disorders. Cue-induced craving during drug withdrawal remains a significant contributor to high relapse rates. Thus, understanding the neurobiological mechanisms of cue-induced drug-seeking behavior is critical. Previous research indicates that the selective 5-HT2A antagonist M100907 attenuates the acquisition of methamphetamine-induced conditioned place preference (CPP) in male and female adult rats. The present study examines the effects of M100907 on expression of methamphetamine-induced drug-seeking behavior using a biased CPP design in adult male and female Long Evans rats (PND 95-112). During conditioning, rats were administered either saline or methamphetamine (1 mg/kg/ml, i.p.) and immediately placed into their initially non-preferred chamber. Rats received either vehicle or M100907 (0.0025, 0.025, 0.1 mg/kg i.p.) 15 minutes prior to expression testing. We found that none of the M100907 doses significantly altered the expression of methamphetamine-induced CPP in male nor female rats.
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methamphetamine, MUD, CPP, 5-HT2A, serotonin
Reyna, Nicole C.. "Antagonizing Serotonin 2A (5-HT2A) Receptors Does Not Attenuate Methamphetamine-Induced Expression of Conditioned Place Preference in Female and Male Rats." (2022). https://digitalrepository.unm.edu/psy_etds/330