Antagonizing Serotonin 2A (5-HT2A) Receptors Does Not Attenuate Methamphetamine-Induced Expression of Conditioned Place Preference in Female and Male Rats

Author

Nicole C. Reyna, University of New MexicoFollow

Publication Date

Spring 5-4-2022

Abstract

Despite the need, there are currently no FDA-approved pharmacological treatments for methamphetamine use disorders. Cue-induced craving during drug withdrawal remains a significant contributor to high relapse rates. Thus, understanding the neurobiological mechanisms of cue-induced drug-seeking behavior is critical. Previous research indicates that the selective 5-HT_2A antagonist M100907 attenuates the acquisition of methamphetamine-induced conditioned place preference (CPP) in male and female adult rats. The present study examines the effects of M100907 on expression of methamphetamine-induced drug-seeking behavior using a biased CPP design in adult male and female Long Evans rats (PND 95-112). During conditioning, rats were administered either saline or methamphetamine (1 mg/kg/ml, i.p.) and immediately placed into their initially non-preferred chamber. Rats received either vehicle or M100907 (0.0025, 0.025, 0.1 mg/kg i.p.) 15 minutes prior to expression testing. We found that none of the M100907 doses significantly altered the expression of methamphetamine-induced CPP in male nor female rats.

Degree Name

Psychology

Level of Degree

Masters

Department Name

Psychology

First Committee Member (Chair)

Nathan Pentkowski

Second Committee Member

Benjamin Clark

Third Committee Member

Jeremy Hogeveen

Language

English

Keywords

methamphetamine, MUD, CPP, 5-HT2A, serotonin

Document Type

Thesis

Recommended Citation

Reyna, Nicole C.. "Antagonizing Serotonin 2A (5-HT2A) Receptors Does Not Attenuate Methamphetamine-Induced Expression of Conditioned Place Preference in Female and Male Rats." (2022). https://digitalrepository.unm.edu/psy_etds/330