Title

Protein biomarker druggability profiling.

Document Type

Article

Publication Date

2-1-2017

Abstract

Developing automated and interactive methods for building a model by incorporating mechanistic and potentially causal annotations of ranked biomarkers of a disease or clinical condition followed by a mapping into a contextual framework in disease-linked biochemical pathways can be used for potential drug-target evaluation and for proposing new drug targets. We demonstrate the potential of this approach using ranked protein biomarkers obtained in neonatal sepsis by enrolling 127 infants (39 infants with late onset neonatal sepsis and 88 control infants) and by performing a focused proteomic profile of the sera and by applying the interactive druggability profiling algorithm (DPA) developed by us.

Publication Title

Journal of biomedical informatics

ISSN

1532-0480

Volume

66

First Page

241

Last Page

247

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