Chemistry ETDs

Publication Date

10-15-1957

Abstract

3,4-Benzpyrene (I), a highly carcinogenic hydrocarbon was first isolated from coal tar in 1933 by Cook, Hewett, and Hieger. Interest in the relationship of structure to carcinogenic activity and correlation of physical properties with carcinogenic potency led to the synthesis of several monomethyl 3,4-benzpyrenes during the decade following the isolation of the parent hydrocarbon. Detailed reviews concerned with the various phases of this research have been prepared. Recently the synthesis of the 1-^2, 7-^3, 8-^(2,5), and 10-^4 methyl-3,4-benzpyrenes completed the series of reported monomethyl derivaives.

Language

English

Document Type

Dissertation

Degree Name

Chemistry

Level of Degree

Doctoral

Department Name

Department of Chemistry and Chemical Biology

First Committee Member (Chair)

Guido Herman Daub

Second Committee Member

Glenn Arthur Crosby

Third Committee Member

Milton Kahn

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