Chemistry and Chemical Biology ETDs

Publication Date

Spring 4-11-2025

Abstract

This is a three-part dissertation. Part 1 is composed of chapters 1-3 which revolves around the optimization of cyclononyne reactivity towards 1,3 dipolar cycloadditions. Specifically, the synthesis and reactivity of sulfate, sulfamate and sulfamide-bearing cyclononynes will be discussed. Chapters 4-5 comprise Part 2 which addresses optimization of ruthenium olefin metathesis towards reversible activation and inhibition. The mechanism of reversible inhibition mediated by a hexaarylbiimidazole photo-inhibitor will be elucidated. Part 3 consists of chapters 6-8 which describes structure-functional relationship studies on carbon dots and harnessing that insight for sensing applications. Data relating to assays performed with explosive analytes will be analyzed to determine how carbon dot structure impacts sensing capabilities.

Project Sponsors

Sandia National Laboratories

Language

English

Keywords

Click chemistry, cyclononyne, ruthenium-catalyzed olefin metathesis, lophyll radicals, carbon-nitride dots, explosive sensing

Document Type

Dissertation

Degree Name

Chemistry and Chemical Biology

Level of Degree

Doctoral

Department Name

Department of Chemistry and Chemical Biology

First Committee Member (Chair)

Terefe G. Habteyes

Second Committee Member

Jean-Hubert Olivier

Third Committee Member

Mark Walker

Fourth Committee Member

William P. Bricker

Fifth Committee Member

John K. Grey

Sixth Committee Member

6) Koushik Ghosh, 7) Sam Leguizamon

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