Event Title

Copper Catalyzed Direct and Tandem Cross-Coupling of Alkyl and 6-Alkenylzinc Reagents

Start Date

8-11-2017 1:30 PM

End Date

8-11-2017 5:30 PM

Description

Cross-coupling is widespread for carbon-carbon bond formation in organic molecules used in synthesizing pharmaceuticals, materials, and commodity chemicals. The integration of cross coupling into tandem reaction manifolds has the potential to create a powerful method to make highly diversified carbo- and heterocycles. Our results show that Cu-catalysts display an excellent ability to execute the direct and tandem coupling of alkyl- and alkenylzinc reagents with aryl/heteroaryl halides. These reaction proceed without complication from β-hydride elimination providing variety of (arylmethyl)carbo- and hetero (N, O)-cycles and coupling of primary, secondary and tertiary alkyl with aryl/heteroaryl halides.

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Nov 8th, 1:30 PM Nov 8th, 5:30 PM

Copper Catalyzed Direct and Tandem Cross-Coupling of Alkyl and 6-Alkenylzinc Reagents

Cross-coupling is widespread for carbon-carbon bond formation in organic molecules used in synthesizing pharmaceuticals, materials, and commodity chemicals. The integration of cross coupling into tandem reaction manifolds has the potential to create a powerful method to make highly diversified carbo- and heterocycles. Our results show that Cu-catalysts display an excellent ability to execute the direct and tandem coupling of alkyl- and alkenylzinc reagents with aryl/heteroaryl halides. These reaction proceed without complication from β-hydride elimination providing variety of (arylmethyl)carbo- and hetero (N, O)-cycles and coupling of primary, secondary and tertiary alkyl with aryl/heteroaryl halides.